【摘 要】
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AIM Mahkota Dewa (Phaleria macrocarpa [Seheff.] Boerl), with effects on antihistamine, anti-oxidation and anticancer, has been used to treat many diseases, including cancer, impotency, haemorrhoids an
【机 构】
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School of Pharmaceutical Science,Zhengzhou University,Zhengzhou,China
【出 处】
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第二届世界天然药物和传统药物药理学学术会议
论文部分内容阅读
AIM Mahkota Dewa (Phaleria macrocarpa [Seheff.] Boerl), with effects on antihistamine, anti-oxidation and anticancer, has been used to treat many diseases, including cancer, impotency, haemorrhoids and diabetes mellitus.The current study is designed to further understand and develop Mabkota Dewa for cancer treatment applications.METHODS AND RESULTS Two benzophenone glucopyranosides were isolated from the nut shell part of Mahkota Dewa.The structures were identified as 2,4 ,6-trihydroxy-4-methoxy-benzophenone-2-0-β-D-glucoside (Mahkoside A) and 2,4, 6-trihydroxy-4-methoxy-6"-acetyl-benzophenone-2-0-β-D-glucoside (Mahkoside B) NMR, HR-MS and UV.Mahkoside B was recognized as a novel compound.Furthermore, a series of benzophenone glucopyranoside derivatives (Compounds 3-18) were synthesized.In order to determine the relationship of structure and activity of the compounds above, several cancer cell lines, including esophageal cancer cell hnes : EC109 and EC9706, stomach cancer cell line: MGC-803 and prostate cancer cell line: PC-3, were randomly selected and cytotoxic activity was evaluated according to the standard SRB (sulforhodamine B) assay.Our results indicated that Compound 18 has significant cytotoxicity against EC109,EC9706, MGC-803 and PC-3, with IC50 ≤ 10 μmol· L-1, indicating its potential activity against cancer cells.CONCLUSION We found that a new derivative of Mahkoside A: Compound 18, demonstrated significant cytotoxicity against cancer cell growth.Future studies will be performed to generate and characterize more derivatives with azotic alkyl group and analyze their structure-effect relationships.
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