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Boundary crossing probabilities of Brownian motion have been broadly applied in numerous areas within physics,biology and chemistry.In this presentation,high-dimensional boundary crossing probabilities for an unbounded convex hull of Brownian motion are used to approximate the distributions of the sojourn time for the first collision of(k+1)independent Brownian motions,and to study threshold regression models,based on the finite Markov chain imbedding technique.Numerical examples with applications are given to illustrate the theoretical results.