【摘 要】
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The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past decade.Usually acid labile hydrazine bonds were formed by conjugating DOX onto side chains.Whi
【机 构】
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Pharmaceutical College of Henan University,Kaifeng,China 475004
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past decade.Usually acid labile hydrazine bonds were formed by conjugating DOX onto side chains.While other drugs such as Paclitaxel (PTX) and cisplatin are not applicable for the lack of special functional groups.In this study, diblock copolymers, poly(ethylene glycol)-hydrazone-poly (lactic acid) (PEG-Hz-PLA) containing pH-responsive hydrazone bond between hydrophilic and hydrophobic segments were synthesized.
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