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Objective To explore the risk factors in patients with acute myocardial infarction complicated with malignant ventricular arrhythmia.Method The study is a retrospective analysis of 322 STEMI patients received primary percutaneous coronary intervention(PPCI) in our hospital from 2010 June to 2012 December.According to malignant ventricular arrhythmia, all patients are divided into: malignant ventricular arrhythmia group (A group):68 cases ; non malignant ventricular arrhythmia group (B group) :254 cases.We observed and compared the two groups patients in general clinical conditions, cardiac ultrasound examination, biochemical indicator detection, C reactive protein(CPR) and plasma brain natriuretic peptide(BNP).Logistic multi-factors regression analysis was performed.Rusults There were no significant difference between A group with B group in aspects : age, sex, hypertension, old myocardial infarction, previous revascularization, heart rate, blood pressure ,et al.There were significant differences in aspects: fasting plasma glucose.8.83±4.81 VS 6.02±2.25 P=0.012; CRP 18.24±12.19 VS 11.06±10.06 P=0.016; BNP 446.04±146.37 VS 315.01±121.11 P=0.009).The logistic regression analysis demonstated :BNP (OR 1.416 95%CI 0.921-3.012 P=0.021) and CRP (CRP OR 1.367 95%CI1.040-4.312 P=0.015) were independent risk factors of patients acute myocardial infraction with ventricular tachyarrhythmias.Conclusions BNP and CRP are independent risk factors of patients acute myocardial infraction with malignant ventricular tachyarrhythmias.It may indicate malignant ventricular arrhythmia incidence increase that the level of CRP and BNP elevated in patients with acute myocardial infarction.