Impairment of the executive attention network in premenopausal women with hormone receptor positive

• 作 者: Xingui Chen Jingjie Zhang Xinglong Hu Kai Wang
• 机 构: Department of Neurology, the First Affiliated Hospital of Anhui Medical University
• 出 处: 华东六省一市第二十三次神经病学学术会议暨2016年浙江省神经病学学术年会
• 发表日期: 2016年8期
• 关键词: Breast cancer Endocrine therapy Attention network test Tamoxifen Prefrontal cort

　　Purpose: Tamoxifen (TAM) is most commonly prescribed for patients with hormone-sensitive breast cancer and exerts agonistic/antagonistic effects on estrogen receptors throughout the body.Accumulating evidence reveals that breast cancer patients receiving TAM manifest cognitive dysfunction;however,whether these patients have a global attention deficit or a more selective impairment of specific attentional networks remains unknown.Methods: In the present study,we sought to explore the attentional function of premenopausal women with hormone receptor positive breast cancer treated with TAM using the attention network test (ANT).The subjects included breast cancer patients receiving TAM (TAM,N=43),breast cancer patients not receiving TAM (non-TAM,N=41),and their matched healthy controls (HC,N=46).The subjects completed the ANT and neuropsychological tests,which measure three independent attention networks and prefrontal cortex executive function performance,respectively.