ATM-mediated phosphorylation of Beclin 1 and mitochondrial fission promote DNA damage-induced mitoph

来源 :2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：axuxiao

【摘要】

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【作者】

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Dan-Dan Li Bao-Xia Li Jian-Wei Jiang Xiao-Qi Wu Ting Sun Wen-Dan Chen Gong-Kan Feng Xiao-shi Zhang Xiao-Feng Zhu

【机构】

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State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-Sen University,Guangzhou 51006

【出处】

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2014医学科学前沿暨第三届个体化治疗与抗肿瘤药物研究新趋向研讨会

【发表日期】

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2014年5期

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　　Mitophagy is a mitochondrial recycling process that primarily promotes cell survival,but can also cause cell death in the presence of prolonged injury.It has been suggested a direct relationship exists between DNA damage and mitophagy, however, the molecular mechanism is poorly understood.In this study, we found topotecan (TPT) activated ATM to induced both DNA damage and mitophagy.Additionally, we observed ATM phosphorylates Beclin 1 directly at Thr57, and that the phosphorylation of Beclin 1 was required for DNA damage-induced mitophagy.

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ATM-mediated phosphorylation of Beclin 1 and mitochondrial fission promote DNA damage-induced mitoph

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