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Myasthenia gravis (MG) is an autoimmune disease of neuromuscular junction,which influences patients quality of life (QOL).Studies had shown that MG patients have poor QOL,but there is little data regarding Chinese MG patients.Severity of the disease was estimated according to the Myasthenia Gravis Foundation of America (MGFA) classification and Quantitative Myasthenia Gravis score.However,due to Chinese medical condition,Ossermans classification is still used mostly in China,and the degree of muscle weakness is assessed by Chinese Score for MG (CSMG).This study was to assess the QOL in ocular,mild and moderate MG patients in China.The data is performed on an undergoing Random Clinical Trail.Consecutive MG patients were enrolled in three hospitals in Shenyang,the northeast of China,from July 2008 to June 2010.Patients,aged 14-75 years old,who were diagnosed to have class I,lla,or Mb MG according to Ossermans classification,were included in this study and classified into ocular,mild and moderate groups.Familial,congenital,or drug-induced MG was excluded.QOL was assessed by the short form-36 (SF-36; range: 0-100 scores; higher scores represent better QOL); severity of the disease was assessed by CSMG (range 12-60 scores; higher scores indicate worse weakness).Differences were tested using analysis of variance and Kruskall-Wallis as appropriate among groups.248 patients,consisting of 110 males and 138 females,were aged 46 ± 18 years old and had a disease history of 47 ± 64 months (median 24 months).These patients were assigned into ocular (27%),mild (35%) and moderate (38%) groups respectively.Fifty-nine patients had at least one comorbidity,71 thymic hyperplasia,and 49 thymectomy.Demographic characteristics among ocular,mild and moderate groups were similar,and there were no differences in disease history,comorbidity and treatment between groups.The ocular group had better QOL and lower CSMG scores than the mild and moderate groups (QOL: 64,57,51 for each group respectively,and CSMG scores: 21,23,26 respectively).There were significant differences in all subscales of the SF-36 among groups,with the exception of general health,social functioning,and role-emotional.The present findings suggest that Chinese MG patients have poor QOL,and ocular MG patients have better QOL than those who had mild and moderate MG,and QOL is influenced by the degree of muscle weakness.