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Purpose/Background: The nasal type of extranodal natural killer NK/T-cell lymphoma (NKTCL) is a rare aggressive lymphoma with poor prognosis.To explore a more effective and feasible treatment, we conducted a phase Ⅱ study of the steroid (Methotrexate, etoposide, dexamethasone, Polyehylene glycolasparaginase, MESA) regimen and investigated its efficacy and toxicity.(ClinicalTrialNCT01933282).