Lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin

• 作 者: MingxiQiao;YaShuYin;XiuliZhao;HaiyangHu;DaWeiChen;
• 机 构: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road
• 出 处: 首届亚洲药物制剂科学研讨会(1st Asian Pharmaceutical Science and Technolog
• 发表日期: 2007年期

　　Purpose: The purpose of this study was to design and evaluate lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin.Methods: Wheat germ agglutinin (WGA)-PLGA conjugates were synthesized by coupling the amino groups of WGA to the carbodiimide-activated carboxylic groups of PLGA.The pharmacodynamical studies on oral administration of WGA-TP5-NPs were performed in FACScan flow cytometry.Results: The values of CD4+/CD8+ ratios were significantly increased compared with that of TP5-NPs (p < 0.01).Conclusion: These results confirmed that the conjugation of WGA onto PLGA nanoparticles effectively improved the intestinal absorption of TP5.