【摘 要】
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The reversible responsiveness of DNA secondary structures to environmental stimuli has enabled to facilitate responsive devices and materials based on pure
【机 构】
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DepartmentofChemistry,TsinghuaUniversity,Beijing100084,China
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The reversible responsiveness of DNA secondary structures to environmental stimuli has enabled to facilitate responsive devices and materials based on pure DNA or hybrid systems.Based on sequence and structure design,we have prepared kinds of pure or hybrid DNA supramolecular hydrogels,which could be formed under physiological condition within a minute at room temperature and without using any organic solvents.By tailoring the length of “sticky ends” of DNA linker,mechanical property of the hydrogel could be varied from hundreds to thousands Pa(G,storage modulus); we also found that the viability of cell in a 4 mm diameter hydrogel is nearly 100%after 24 hours incubation from top in plastic tubes.Additionally,the hydrogels show an excellent multiple responsiveness including pH,DNA restriction enzymes,protease digesting,temperature etc.,which enable easy removal after cell culture.We believe these hydrogels have great potential in tissue engineering,especially for 3D cell printing.
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