Pedal and brake the innate immune sensing of pathogen and damage

• 作 者: Shengduo Liu Qian Zhang Shiying Wu Fansen Meng Shasha Chen Pinglong Xu
• 机 构: LifeSciencesInstituteandInnovationCenterforCellSignalingNetwork,ZhejiangUniversity,Hangzhou
• 出 处: 中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
• 发表日期: 2018年10期
• 关键词: innate immune sensing protein modification cellular damage interferon infection

　　Cytosolic RNA/DNA sensing warns host cells both microbe invasion and cellular damage,and to initiate counter measures by igniting cascades through MAVS/STING adaptors,TBK1/IKKε kinases and IRF3 transcription factor.Yet,how the magnitude of this recently defined innate immune sensing is controlled remains largely unknown.