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【目的】探讨双酚A与女童性早熟发病的关系;首次尝试了解生活习惯与双酚A暴露及性早熟的关系。【方法】收集2011年7-12月于本院门诊就诊的性早熟病例组和正常对照组女童各44例;采用高效液相色谱法分别检测两组女童尿液双酚A浓度;通过自编问卷了解日常生活中可能存在双酚A暴露的生活习惯。【结果】病例组和对照组尿液双酚A检出率分别为70.45%和43.18%,差异有统计学意义(χ2=6.67,P<0.05);病例组尿液双酚A浓度高于对照组(Z=3.49,P<0.01);是否饮用桶装水热水可能是女童患有性早熟的弱危险因素(β=0.967 8,χ2=3.870 3,P=0.049 1,OR=2.632,95%CI:1.004～6.903)。【结论】双酚A暴露可能与女童性早熟发病有关;正常对照组女童亦有较高的双酚A暴露率;尿样更适合用来评估人体双酚A暴露情况;常饮用桶装水热水可能增加女童患性早熟的风险;正确合理地使用塑料制品十分重要。
【Objective】 To explore the relationship between bisphenol A and the development of precocious puberty in girls and to understand the relationship between lifestyle and bisphenol A exposure and precocious puberty for the first time. 【Methods】 Forty-four cases of precocious puberty cases and normal control girls from July to December in 2011 were enrolled in this study. Urinary bisphenol A concentration in urine was detected by high performance liquid chromatography (HPLC) Questionnaire to understand the daily life may be exposed to bisphenol A habit. 【Results】 The detection rates of urinary BPA in case group and control group were 70.45% and 43.18%, respectively, with significant difference (χ2 = 6.67, P <0.05). Urinary BPA concentration in case group was higher than that in control group Group (Z = 3.49, P <0.01). Whether drinking bottled hot water may be a weak risk factor for girls with precocious puberty (β = 0.967 8, χ2 = 3.870 3, P = 0.049 1, OR = 2.632, 95 % CI: 1.004 ~ 6.903). 【Conclusion】 The exposure of bisphenol A may be related to the incidence of precocious puberty in girls. The normal control group of girls also have a higher exposure rate of bisphenol A; the urine samples are more suitable for assessing the exposure of bisphenol A in the human body; Water may increase the risk of girls becoming precocious; it is important that plastic products are used correctly and reasonably.