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Objective To Investigate the monitoring items.nursing measures and treatment effect of continuous renal replacemenL therapy (CRRT) on severe hemorrhagic fever with renal syndrome (HFRS) patients.Methods Retrospective analysis was used for the clinical data of 24 HFRS patients treated with CRRT from Dec 2011 to Dec 2012 in our hospital.Continuous venous-venous hemofiltration (CWH) was chosen for CRRT treatment of all patients.Nine comprehensive nursing measures were taken.The responsibility system nursing care were applied.In the course of treatment.patients were observed for adverse reactions,abnormal situation,nursing effect and clinical outcome.Results TObal24 severe HFRS patients.8 cases were cured clinically,10 cases were improved.and the recovery rate was 75.0%.3 cases were discharged by themselves.and 3 cases were died.During the treatment of CRRT,3 cases had low blood pressure response,2 cases were agitated.2 cases occurred the tube clotting,1 case had femoral vein errhysis,1 case happened machine fault.Low blood pressure was the most common adverse reaction (incidence rate 12.5%) of patlents in CRRT treatment.Conclusions CRRT is an important therapeutic tool and method for severe HFRS patients.In order to prevent from the occurrence of adverse reactions.to shorten the course of disease.to improve effectively the patient's condition and prognosis,to raise the clinical cure rate of HFRS patients,nurses should give the patients accepted CRRT treatment with humanized.careful,meticulous observation and nursing,and strictly carry out standard operation.