First identification of isatin-β-thiosemicarbazones as novel inhibitors of New Delhi metallo-β-lacta

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：oklizheng

【摘要】

：

New Delhi metallo-β-lactmase-1(NDM-1)catalyzes the hydrolysis of β-lactam antibiotics and cleaves the β-lactam ring of the molecule,conferring resistance against these medicines to bacteria.

【作者】

：

Guo-Qing Song Wei-Min Wang Zai-Shun Li Ying Wang Jian-Guo Wang

【机构】

：

State-Key Laboratory and Research Institute of Elemento-Organic Chemistry,National Pesticide Enginee

【出处】

：

中国化学会第十届全国化学生物学学术会议

【发表日期】

：

2017年10期

【关键词】

：

NDM-1 isatin-β-thiosemicarbazones in vitro enzyme inhibition

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　New Delhi metallo-β-lactmase-1(NDM-1)catalyzes the hydrolysis of β-lactam antibiotics and cleaves the β-lactam ring of the molecule,conferring resistance against these medicines to bacteria.

其他文献

沉淀聚合法制备生物基耐高温聚合物微球

随着石油资源的日益枯竭，可再生的生物基资源越来越受到人们的广泛关注。作为一种典型的生物质烯类资源，茴香烯虽然广泛的存在于香辛料作物精油中，但由于其聚合相对困难，高分子合成方面应用较少。

会议

生物质耐高温沉淀聚合微球

基于交联改性大豆分离蛋白的超级电容器及性能研究

随着新能源的迅速发展，超级电容器作为一种新型的储能元件引起了广泛关注。本论文以可再生、环境友好的大豆分离蛋白为基体材料，通过物理、化学两种交联方式，制备了大豆蛋白基膜材料，应用于中性水相超级电容器中，通过电化学阻抗、循环伏安和恒流充放电技术，系统地研究了超级电容器单体器件的电化学性能，探究了物理和化学改性对于超级电容器性能的影响。

会议

大豆分离蛋白超级电容器交联改性电化学性能

聚(十三烷二酸环乙撑酯-δ-戊内酯)的合成及结构与性能关系的研究

利用无毒的三苯基铋为催化剂催化生物基来源的两种单体十三烷二酸环乙撑酯(EB)和δ-戊内酯(δ-VL)开环聚合，得到了一系列EB 含量由0-100％的不同比例的共聚物.150℃条件下在相对较短的时间内(36h)得到了高分子量的聚合物.

会议

生物高分子十三烷二酸环乙撑酯δ-戊内酯韧性聚合反应动力学

Rationally designed small molecule inhibitors of glucose transporter 1

Due to the elevated anaerobic metabolism of cancerous cells,their demand for glucose is much higher than that of normal cells.

会议

Glucose transporter 1InhibitorConformationCrystal

Exploration of bioactive ruthenium(Ⅱ)-arene complexes containing 18β-glycyrrhetinic acid ligands

Constructing novel metal-arene complexes containing bioactive natural-product derived ligands is an important approach to further drug design.Herein,we reported two novel ruthenium(Ⅱ)-arene complexes(

会议

ruthenium(Ⅱ)-arene complexes18β-glycyrrhetinic acidanticancer

Design and Synthesis of Pyruvate Dehydrogenase Complex E1 Inhibitors with Cyanobacteria Inhibitory A

The pyruvate dehydrogenase complex(PDHc)in microorganism plays a vital role in cellular metabolism and catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A(

会议

PDHc-E1 inhibitor4-AminopyrimidineCyanobacteriaMolecular docking

Boron-containing compounds in drug discovery and chemical biology

An interesting class of cyclic boron-containing compounds,benzoxaboroles,were first synthesized in 19571 while its medicinal usage had remained unexplored for fifty years until tavaborole(Kerydin)(Fig

会议

Design,synthesis and biological evaluation of new 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

To find novel pyruvate dehydrogenase complex E1 component(PHDc-E1)inhibitors as fungicides,two series of 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives were designed,synthesized,and evaluated for

会议

PDHc-E1fungicidal activity

Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease

The worldwide outbreak of severe acute respiratory syndrome(SARS)in 2003 had caused a high rate of mortality.Main protease(Mpro)of SARS-associated coronavirus(SARS-CoV)is an important target to discov

会议

SARS-CoV Mproaromatic disulfidemolecular dockingin vitro activity

Design of Pt(Ⅳ)Prodrug by Targeting Epigenetic Alterations and Binding Human Serum Albumin for Drug

Aberrant epigenetic alterations of tumor suppressor genes have been recognized as a driving force in cancer.Histone deacetylases(HDACs),for example,are promising targets for cancer due to their crucia

会议

EpigeneticsICLsHDACsProdrugPlatinum(Ⅳ)

First identification of isatin-β-thiosemicarbazones as novel inhibitors of New Delhi metallo-β-lacta

其他学术论文