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Objective To compare the noninvasive Keratograph tear breakup time(NIKBUT)and tear meniscus height(TMH)of patients with dry eye disease(DED)and healthy control subjects using Keratograph 5M(K5M)and to investigate the role of NIKBUT and TMH in the diagnosis of DED.Mehthods A prospective study.One hundred and ten eyes with DED(DED group)and 108 healthy control eyes(Control group)were enrolled in this study.