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Sequence-based peptidomimetics have repeatedly been shown to display biologic activities similar to those of the protein from which they were derived.However little experimental data are available to demonstrate that such peptides indeed reproduce the binding mode of the corresponding proteins.We have used peptide micro-arrays, phage-display and mutational analysis by surface plasmon resonance to analyze the binding properties of synthetic peptides based on epitope and paratope sequences, representative of linear binding sites and of highly structured sites, respectively.