High-frequency repetitive transcranial magnetic stimulation promotes neurogenesis, and reduces acute

• 作 者: XiquanHu[1]JingLuo[1]LiyingZhang[1]QingjieZhang[1]YewLongLo[2]RuxunHuang[3]ZhongPei[3]
• 机 构: Department of Rehabilitation Medicine, the Third Affiliated Hospital,Sun Yat-sen University
• 出 处: 第五届粤港澳台物理医学与康复学学术会议暨2014年广东省医学会物理医学与康复学学术会议
• 发表日期: 2014年期

　　Repetitive transcranial magnetic stimulation (rTMS) has rapidly become an attractive therapeutic approach for stroke.However,its underlying mechanism remains elusive.This study is aimed to investigate whether high-frequency rTMS can promote neurogenesis and to examine the role BDNF-TrkB pathways in rTMS-induced functional recovery in a rat model of middle cerebral artery occlusion.Ischemic rats received either high-frequency rTMS at 20Hz or intermittent theta burst stimulation (iTBS) daily for 2 weeks.High-frequency rTMS and iTBS significantly improved the neurological function and reduced infarct volume.Moreover,High-frequency rTMS and iTBS significantly promoted neurogenesis as evidenced by increased DCX -positive and Ki67/nestin-positive cells in the ipsilateral side.These beneficial effects were in conjunction with the elevation of BDNF and TrkB protein in the peri-infarct region,indicating that high-frequency rTMS promotes neurogenesis and reduces acute ischemic brain damage possibly by the promotion of BDNF signaling pathways.