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A helical structure is one of the most fundamental and prevailed motifs in biological materials,such as DNA, collagen, and proteins.Furthermore, some of them exhibit reversible helicity switching according to environmental changes and regulate their biological functions.Inspired by these diverse roles of helical structures in the biological system, we have developed a rational strategy for designing the artificial helical supramolecular structures,which exhibits perfectly reversible helicity switching without changing thermodynamic parameters.I will discuss the details in my poster presentation.