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泛素-蛋白酶体系统是细胞内非常重要的蛋白质降解调节系统。蛋白质泛素化和去泛素化调节的动态平衡,影响或者调节细胞的生长发育、信号转导、神经病变或者肿瘤等许多细胞生理病理过程。目前研究证实,细胞内广泛存在多种去泛素化酶,通过选择性地降解或稳定癌基因、抑癌基因以及其他与细胞生物学相关的底物蛋白,与肿瘤的发生、发展密切相关。本文对去泛素化酶的分类、结构、作用机制、活性调节及其在肿瘤发生中的作用作一综述,拟为研究肿瘤的发生、发展提供新的理论依据,并有助于我们开发以及应用针对去泛素化酶的分子靶向药物。
The ubiquitin-proteasome system is an intracellular very important system of protein degradation regulation. The dynamic balance of protein ubiquitination and deubiquitination regulates, or regulates, many cellular processes such as cell growth and development, signal transduction, neuropathy, or cancer. The current study confirmed that there are a wide range of detoxification ubiquitin enzymes widely in the cell by selectively degrading or stabilizing oncogenes, tumor suppressor genes and other cell biology related substrate proteins, and the occurrence and development of tumors are closely related. This review summarizes the classification, structure, mechanism of action, activity regulation and the role of deubiquitinase in tumorigenesis, and provides a new theoretical basis for the study of the occurrence and development of tumors, and help us to develop and Applications Targeted drugs for deubiquitinating enzymes.