Single nucleotide polymorphisms within three C-type lectin genes are associated with colorectal canc

• 作 者: Shuu Lu Melanie Bevier Stefanie Huhn Juan Sainz Jesus Lascorz Barbara Pardini Alessio Naccarati Ludmila Vodickova Jan Novotny Kari Hemminki Pavel Vodicka Asta F(o)rsti
• 机 构: Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, German
• 出 处: 第十二届全国大肠癌学术会议暨江苏省第九届腹腔镜外科会议
• 发表日期: 2015年1期
• 关键词: CD209 colorectal cancer MBL polymorphism REG4

　　Background: Inflammatory responses play a vital role at different stages of colorectal carcinogenesis.C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tnmors.Methods: We genotyped 15 potentially functional single nucleotide polymorphisms (SNPs) in three C-type lectin genes, CD209, MBL2 and REG4, and assessed their associations with CRC risk in a Czech case-control study of 1353 CRC cases and 767 healthy controls.We also analyzed these SNPs in relation to overall and event-free survival in 414 patients.Results: Three CD209 SNPs were associated with CRC risk.Minor allele carriers of the promoter SNP rs2287886 had an increased risk of CRC (OR 1.30, 95%CI 1.08-1.56), while minor allele carriers of two 3UTR SNPs, rs7248637 and rs4804800, had a decreased risk (OR 0.74, 95%CI 0.60-0.91 and OR 0.81, 95%CI 0.66-1.00, respectively).Multivariate survival analyses showed that patients carrying either the REC4 rs2994809 T allele or the REG4 rs2994811 C allele had a significantly increased risk of death compared to the carriers of the wild-type genotype (HR 1.87, 95%CI 1.23-2.85 and HR 1.38, 95%CI 1.01-1.89, respectively).Carriers of the rs2994809 T allele also had a decreased event-free survival (HR 1.99, 95%CI 1.17-3.37).Conclusion: We show for the first time that SNPs in CD209 may affect CRC risk, while SNPs in REG4 may be useful markers for CRC progression.