Prediction of Drug Disposition in Diabetic Patients by Means of Physiologically Based Pharmacokineti

• 作 者: JiaLI;Hai-fangGUO;LiLIU;Xiao-dongLIU;
• 机 构: Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing,Chi
• 出 处: 第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium
• 发表日期: 2013年期

　　Accumulating evidences have showed that pharmacokinetics of some drugs was altered by diabetes mellitus, leading to changes of pharmacodynamic/toxic effects.Pro-dosage prediction ofpharmacokinetics was needed for appropriate optimization of dose for diabetic patients.Aim of study was to develop a novel physiologically based pharmacokinetic (PBPK) model for predicting pharmacokinetics of drugs in type 2 diabetic patients quantitatively.