Synthesis and Anti-cancer Activities of Fluorinated Apigenin Derivatives

• 作 者: Xu Yao Zehua Yang Zhuo Liu Jin Long Menghui Xiang Yi Gao Baojun Su Ye Zhang Hong Li Siyu Wu Tingjuan Wu Xing Zheng
• 机 构: InstituteofPharmacy&Pharmacology,UniversityofSouthChina,Hengyang,421001,China;HunanProvinceCooperati
• 出 处: 中国化学会第十四届全国氟化学会议
• 发表日期: 2016年11期
• 关键词: Anti-cancer activities Fluorinated apigenin 5-Fu SAR

　　A novel series of fluorinated apigenin derivatives were synthesized and in vitro inhibitory activities against HL-60,HT-29 and SGC-7901 tumor cell lines were evaluated by the standard methyl thiazole tetrazolium (MTT) method.The results showed that some of fluorinated apgenin derivatives had higher anticancer activity than 5-Fu.