Molecular Network Dynamics as a basis for Specificity

来源 :Workshop on Systems Biology(系统生物学研讨会) | 被引量 : 0次 | 上传用户:wylalone
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Cellular responses to stress agents such as inflammatory cytokines or pathogensinvolve transcription factors that exhibit complex dynamics.I will discuss our recentstudies on whether these dynamics represent a signaling code that may specify cellulargene expression responses,and to what extent such a code may be harnessed toachieve greater specificity when targeting pleiotropic signaling hubs pharmacologically,or when identifying prognostic biomarkers to determine the course treatment.
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