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Objective To evaluate the efficacy and safety of Wenxinkeli and metoprolol for atrial fibrillation.Methods We searched The Cochrane Library(2013.12), Pubmed(the commencement Of the database to 2013),EMBASE (the commencement Of the database to 2013),China Nation Knowledge infrastructure (the commencement Of the database to 2013) and the Wanfang Data base (the commencement Of the database to 2013) ,Weipu Data base (the commencement Of the database to 2013) ,CBM (the commencement Of the database to 2013)on computers for parallel group randomized controlled trials(RCTs) comparing Wenxinkeli combined metoprolol and metoprolol for patients with atrial fibrallation.Three researchers selected the trials based on the include and exclude criterions and then extracted the data including sample size,basic information of patients,interveningmeasure,course of treatment, clinicalefficacy, adverseeffect, and so on.Assessed the quality of each trial using the tool for assessing risk of bias recommended by Cochrane collaboration independently.After cross checked, The RevMan5.1 software provided by the Cochrane Collaboration was used to perform Meta-analysis.Results Eleven RCTs were involved.All trial methodologies are low quality.A total of 805 patients.422 patients were treated using Wenxinkeli combined metoprolol as the treatment group.383 patients were treated using metoprolol as the control group.There are 265 cases whos symptoms and onset of atrial fibrillation were improved in the treatment group and 185 cases in the control group.25 cases in the treatment group happened Adverse effect and 26 cases in the control group.Meta-analysis showed that:Wenxinkeli combined metoprolol had better curative effect on atrial fibrillation than metoprolol:symptom-improvement (RR=1.34, 95% CI: 1.17-1.54),Reduce the onset of atrial fibrillation (RR=1.31,95%CI:1.15-1.48),symptom-improvement also reduce the onset of atrial fibrillation (RR=1.23,95%CI: 1.14-1.34).But there was not significant difference in Adverse Effects Rate between the two groups (RR=1.00, 95%CI:0.59-1.69,P=0.41).Conclusions Compaired to metoprolol,Wenxinkeli combined metoprolol had better curative effect.The Adverse Effect Rate between two groups was not significant different.But because of little-scale,inferior quality, biase risk of these trials,large-scale,rational design,multicenter RCTS were needed to confirm our conlusions.