【摘 要】
：
c-Myc 是细胞中重要的转录因子,据统计,它负责转录了基因组中约15％-20％的基因;在细胞增殖、分裂、分化、死亡及代谢等过程中起了重要调控作用.由于c-Myc 在细胞中转录时间非常
【出 处】
：
2015(第三届)非编码RNA学术研讨会
论文部分内容阅读
c-Myc 是细胞中重要的转录因子,据统计,它负责转录了基因组中约15％-20％的基因;在细胞增殖、分裂、分化、死亡及代谢等过程中起了重要调控作用.由于c-Myc 在细胞中转录时间非常短,所以它水平的维持主要通过蛋白质降解途径来实现,FBW7 是它的最重要E3 泛素连接酶.我们最近的研究发现了一个由c-Myc 转录的新的长非编码lincRNA-32,它可以和编码的FBW7 mRNA 竞争结合微小miR568;通过连接c-Myc 对它转录及它对c-Myc 的降解,这一competing endogenous RNA(ceRNA）保持了c-Myc 在细胞中的的稳态.
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