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BACKGROUND: Chronic inflammation is involved in atherosclerosis, and macrophage cells play important role in this process.The aim of the study was to investigate the anti-inflammatory effect of C1q/tumor necrosis factor (TNF)-related protein 9 (CTRP9) in RAW264.7 mouse macrophage cells treated with oxidized low density lipoprotein (oxLDL), and to explore its mechanism.