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The pathogen Staphylococcus aureus,a leading cause of human bacterial infections worldwide,is an opportunistic bacterial pathogen responsible for a diverse spectrum of human diseases.which are from mild and common skin and soft tissue infections to severe,necrotizing and highly invasive disease.Given the high prevalence of S.aureus infections,it is, perhaps, not surprising that-30% of non-institutionalized individuals are permanently colonized with the organism.Therefore,S.aureus may be considered a component of normal human flora.These findings are noteworthy because nasal carriage of S aureus has been associated with subsequent infection.