【摘 要】
：
cMyc是一个重要的癌基因,被发现在30-50％的人类肿瘤中异常表达并促进肿瘤的发生发展。目前已知cMyc几乎调节糖代谢过程的所有酶,我们的前期研究也曾揭示了癌基因cMyc与HIF
【机 构】
：
中国科学技术大学,合肥,230027
【出 处】
：
第11届海峡两岸细胞生物学学术研讨会
论文部分内容阅读
cMyc是一个重要的癌基因,被发现在30-50％的人类肿瘤中异常表达并促进肿瘤的发生发展。目前已知cMyc几乎调节糖代谢过程的所有酶,我们的前期研究也曾揭示了癌基因cMyc与HIF1相互作用调节肿瘤细胞中的Warburg Effect,即肿瘤细胞代谢重编程。除了糖代谢之外,我们还发现cMyc通过调节谷氨酰胺酶GLS1而调节谷氨酰胺代谢,进而影响肿瘤的发生发展。近期我们进一步发现,cMyc广泛地调节肿瘤细胞中丝氨酸从头合成过程(Serine synthesis pathway,SSP),并由此影响营养匮乏状态下肿瘤细胞的存活及增殖。我的汇报将讨论cMyc对肿瘤细胞代谢重编程的调控,并聚焦于cMyc对氨基酸代谓谢的调控及其对肿瘤发生发展的影响。
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