MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户:tianxia108
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  Objective Hepatocellular carcinoma(HCC)is the 4th most common cause of cancer-related mortality worldwide.Current treatments for HCC include surgical resection,liver transplantation,and local ablation for early-stage disease,but they are not effective.The small molecule multi-kinase inhibitors,sorafenib(first-line use),regorafenib(second-line use)and lenvatinib(first-line use)have been approved by the U.S.Food and Drug Administration(FDA)to treat advanced HCC.Cabozantinib treatment showed positive results in second-line use among patients with previously treated advanced hepatocellular carcinoma.
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