Self-assembled, dual drug carrying polymer-drug conjugate for co-delivery

• 作 者: YanLi;DongluShi;YongyongLi;
• 机 构: The Institute for Biomedical Engineering & Nanoscience,School of Medicine,Tongji University,Shanghai
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　Due to molecular complexity,co-delivery of different agents aiming at various targets is becoming increasingly important to exert different toxicity profiles towards cancer cells.The strategy of codelivery is to maximize the therapeutic effect,overcome drug-resistance as well as decrease side effects [1].Polymer-drug conjugates are widely used drug delivery technologies in which a drug is usually covalently bound to a polymeric carrier,normally via a biodegradable linker.To exert their therapeutic activity,the drugs need to be carefully conjugated onto a polymeric backbone and subsequently be released fiom the carrier at a specific site.The drug release behavior of different drugs such as relative drug release rate and sequential drug release should be well regulated so as to synchronize with disease demand.