随着新医改的推进,各地各级医疗机构正在逐步实施药品零差价,这为医院制剂的发展带来了新的机遇;与此同时,国家对于医疗机构制剂研制及质量标准的要求不断提高,也为医院制剂带来了新的挑战.在这一新形势下,我们应当紧跟国家、军队医疗机构制剂的政策导向;加强与高校、科研院所的合作;采用先进的制剂技术,改善、提高现有制剂的处方、工艺及质量标准;开发药物新剂型;针对疑难杂症开发特色中药制剂,开展特色医疗,满足临床
In the past several years, gene therapy has received significant attention due to its potential application in the replacement of dysfunctional genes and treatment of acquired diseases.However, naked
Aim: To develop a theranostic nanoemulsion (TNE) that can co-deliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB).Materials & methods: T
RNA interference (RNAi) is emerging as one of promising strategies for tumor therapy, especially for inhibiting tumor metastasis.However, an efficient and safety non-virus delivery system for clinical
The development of effective therapies for central nervous system (CNS) disorders remains a critical challenge for the pharmaceutical industry.One of the most important obstacles for drug brain delive
Purpose: To improve tumor targeting ability and anti-glioblastoma efficacy, a cyclic-RGD decorated polymeric micelle carrying stapled PMI was designed for the first time to target tumors, activate p53
Drug packaging materials should present a good compatibility with drugs so as to ensure the stability, effectivity as well as the safety of the contained drug products, avoiding introducing leachables
The aim of this study was to develop and optimize the coating formulation for nTanshinone ⅡA (TA) sustained-release pellets in order to meet the needs of clinical application.The plasma concentration-
Objective: The aim of our study is to develop novel polymeric micelles to achieve specific tumor targeting and rapid intracellular drug release at target.Methods: By covalently attaching stearic acid
10-Hydroxycamptothecin (HCPT) and doxorubicin (DOX) are inhibitors of topoisomerase Ⅰ and topoisomerase Ⅱ respectively.Therefore, combination therapy using HCPT and DOX is possible and significant to