【摘 要】
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Armillariella mellea is an edible fungus used in the formulation of neutraceuticals and functional foods.The growth curve showed that the 49-day culture achieved the maximum dry mass accumulation with
【机 构】
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National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei
【出 处】
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第十四届全国中药和天然药物学术研讨会暨第十三届中药全球化联盟大会
论文部分内容阅读
Armillariella mellea is an edible fungus used in the formulation of neutraceuticals and functional foods.The growth curve showed that the 49-day culture achieved the maximum dry mass accumulation with a value of 15.73 g/L.Effects of the ethanolic extract of A.mellea on lipopolysaccharide (LPS)-induced inflammation-related cytokines of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in RAW264.7 macrophages and the secretion of cytokine monocyte chemotactic protein (MCP)-1 in EA.hy926 cells were evaluated.A time-course study revealed that the 49-day-cultured A.mellea showed maximal inhibition of TNF-α, IL-6, and MCP-1 with values of 13.74％, 0％, and 37.49％, respectively.Secretion of MCP-1 by EA.hy926 cells induced by TNF-α was significantly reduced by 61％ and 62％ with 35-and 49-day-cultured A.mellee, respectively.IK-B degradation induced by LPS in macrophages or TNF-α in endothelial cells (ECs) was reversed by 49-day-cultured A.mellea.Suppression of NF-κB activation might have been responsible for the anti-inflammatory effects.
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