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In this paper,HMME-TiO2 nanocomposites was synthesized and characterized through TEM,Uv-vis spectra,Zeta potential,FTIR spectra.The characterization results show that HMME was successfully conjugated onto the surface of TiO2.It can be seen from the TEM images the average size of HMME-TiO2 conjugation is nearly spherical and the particle size range from 20 to 28 nm.Compared with HMME,the B bands of HMME-TiO2 were much broader and lower while in the region of Q bands the absorption peaks of HMME-TiO2 are higher than that of HMME.Encapsulation efficiency of HMME-loaded TiO2 was assessed and calculated as 45.46%.FTIR spectra show the bonding between TiO2 and HMME was through the hydrogen-bonding between COOH and OH bonds.Fluorescence microscope results demonstrated HMME-TiO2 mainly distributed in the membrane and cytoplasm of SCC cells and its best incubation time is six hours.After treated with HMME-TiO2 plus light irradiation(1.8J/cm2,632nm),the viability of SCC cells turned to 32.96%is much lower than that treated with HMME plus light irradiation.It can be concluded that the combination of HMME and TiO2 will enhance the PDT efficiency of HMME.In the process of HMME-TiO2 mediated PDT,as a kind of photosensitizer HMME can induce the death of SCC cells,meanwhile it can transform electron to the conductive band of TiO2 stimulating the photocatalytic activity of TiO2 under visible light.The photocatalytic of TiO2 can also induce the death of SCC cells.The combination of these two effects lead to more SCC cells died.