IRF3 detrimental to Pseudomonas aeruginosa-induced pneumonia by inhibiting neutrophil recruitment

• 作 者: Zhenghao Piao Haiying Yuan Liyun Shi
• 机 构: Department of Basic Medical Science, School of Medicine, Hangzhou Normal University,Hangzhou, Zhejia
• 出 处: 浙江省免疫学会第十次学术大会
• 发表日期: 2016年8期
• 关键词: IRF3 Neutrophil recruitment P.aeruginosa

　　Pseudomonas aeruginosa (P.aeruginosa) is the major pathogen in the morbidity and mortality of ventilator associated pneumonia.Interferon regulatory factor 3 (IRF3) is a transcription factor,phying an important role in the immune response to viral infection via IRF3/IFN-3 signaling pathway.Investigation on the functional characteristic of IRF3 in bacterial infection is has received increasing interest.