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Enhanced external counterpulsation (EECP) is noninvasive,safe,and effective for stable angina.We have reported that the development of functional collateral vessels is one of the mechanisms of EECP therapy using ammonia positron emission tomography (PET).The efficacy of heparin treatment on collateral growth is shown in several clinical studies.We evaluated whether EECP combined with intravenous heparin injection is effective for exercise capacity and oxygen metabolism of ischemic myocardium in stable angina.