Ghrelin Receptor Agonist, GHRP-6, Produces Antinociceptive Effects at the Supraspinal Level via the

• 作 者: JieWei;PingZeng;Fu-YanLiu;
• 机 构: Department of Physiology,Medical College of Nanchang University,Bayi Road 461,Nanchang,Jiangxi,33000
• 出 处: 第十三届中国国际多肽大会
• 发表日期: 2014年期

　　GHRP-6 is a synthetic agonist of ghrelin receptor.GHRP-6 has similar physiological functions with ghrelin[1-2].In our previous study,ghrelin(i.c.v.)could induce analgesic effect through an interaction with GHS-R1α and with the central opioid system in the acute pain in mice[3].To date,the function of GHRP-6 in pain processing was not understood.Therefore the aim of this study was to investigate the effects of GHRP-6 on pain modulation at supraspinal level in mice using the tail immersion test.Intracerebroventricular(i.c.v.)administration of GHRP-6(0.1,0.3,1,3 and 10 nmol/L)produced a concentration-and time-related antinociceptive effect.This effect could be fully antagonized by GHS-R1α antagonist [D-Lys3]-GHRP-6,indicating that the analgesic effect induced by GHRP-6 is mediated through the activation of GHS-R1α.