【摘 要】
：
系统评价参附注射液治疗冠心病心绞痛的有效性及安全性.检索Embase、Pubmed、Cochrane图书馆、ClinicalTrials.gov、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)以及万方数字化期刊全文数据库等,筛选并纳入采用参附注射液辅助治疗冠心病心绞痛的随机或半随机对照试验,依据Cochrane协作网工具评价纳入文献的方法学质量,
【出 处】
：
2016年浙江省医学会心电生理与起搏学术年会
论文部分内容阅读
系统评价参附注射液治疗冠心病心绞痛的有效性及安全性.检索Embase、Pubmed、Cochrane图书馆、ClinicalTrials.gov、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)以及万方数字化期刊全文数据库等,筛选并纳入采用参附注射液辅助治疗冠心病心绞痛的随机或半随机对照试验,依据Cochrane协作网工具评价纳入文献的方法学质量,并应用STATA12.0软件进行统计学处理.最终17项研究入选,包括随机对照试验(RCT) 16项和临床对照试验(CCT)1项,总计1309例患者,其中659例患者接受参附注射液治疗.Meta分析结果显示,与常规治疗相比,联用参附注射液能显著改善冠心病患者心绞痛症状(0R=3.38,95％CI：2.47～4.64,P=0.000)及心电图缺血性ST-T改变(0R=3.30,95％CI：2.22～4.90,P=0.000).Meta回归显示患者平均年龄与临床疗效OR(β=0.17)及心电图疗效OR(β=1.15)均存在正相关性.参附注射液相关并发症发生率为3.4％,无严重不良反应.现有临床证据表明参附注射液能显著改善冠心病心绞痛患者临床症状及心电图缺血表现,并具有良好的安全性.
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