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Risky decision making is a complex process that involves weighing the probabilities of alternative options that can be desirable,undesirable,or neutral.Individuals vary greatly in how they make decisions either under ambiguity and/or under risk.On the one hand,it has been suggested that genes played an important role in risky decision making.Twin studies have estimated that genetic effects account for about 20% of the variance in risk taking behavior (Cesarini et al.,2009).Studies have revealed that genes related to both dopamine and serotonin neurotransmitter systems,which are believed to underlie reward and emotional processing,are closely related to risky decision making.On the other hand,environment has also been suggested to determine the profile of decision making.In this talk,we will (a) briefly review the literature on genetic correlates of decision making,(b) describe facets of individual differences in decision making ability based on the Iowa Gambling Task,(c) report our findings of the role of two genetic markers (namely,5-HTTLPR and COMT) in risky decision making as well as gene-environment interaction of decision making,(d) explore the possible neural mechanisms underlying the genetic contribution to individual differences in risky decision making,and (e)discuss future directions.