Doped Inorganic Nanoparticles as Synergistically Enhanced T1-T2 Dual-Modal MRI Contrast Agents

• 作 者: Zijian Zhou Dengtong Huang Zhenghuan Zhao Jianfeng Bao Zhong Chen Jinhao Gao
• 机 构: State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biolog
• 出 处: 中国化学会第28届学术年会
• 发表日期: 2012年10期
• 关键词: Contrast agents inorganic nanoparticles T1-T2 dual-modal synergistic enhancement

　　The combination of multiple imaging modalities can yield complementary diagnostic information and offer synergistic advantages over the single modality.The T1-T2 dual-modal strategy for magnetic resonance imaging (MRI) has attracted considerable interest because it can give the highly accurate diagnostic information by the beneficial contrast effects in both T1 imaging with high tissue resolution and T2 imaging with high feasibility on detection of a lesion.We presented the monodisperse gadolinium-doped iron oxide (GDIO) nanoparticles can serve as a strong and synergistically enhanced T1-T2 dual-modal contrast agent (DMCA)[1] for MRI.Embedding Gd species into superparamagnetic nanoparticles can render the advantage of enhanced magnetizations between each other under external magnetic fields and result in the synergistic enhancement of T1 and T2 contrast effects.MRI phantom testes indicated the r1 and r2 values of GDIO nanoparticles are 69.5 mM-1·S-1 (Gd) and 146.5 mM -1·S-1 (Fe),respectively.The in vivo MR imaging of mice showed that there are large relaxivity changes in both T1 and T2 imaging of liver regions.The in vitro and in vivo studies demonstrated GDIO nanoparticles have the unique capability to simultaneously show significant changes of MR signals in both T1 and T2 imaging,which can provide more comprehensive imaging information and lead to higher sensitivity and diagnostic accuracy.[2-3] This strategy may open up a new avenue for design of novel T1-T2 DMCAs.