【摘 要】
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Background Diabetes mellitus (DM) is regarded as an independent predictor of adverse outcomes in patients with acute myocardial infarction (AMI), which is in accordance with weaken ischemia-induced ne
【机 构】
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The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing,Jiangsu,China
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Background Diabetes mellitus (DM) is regarded as an independent predictor of adverse outcomes in patients with acute myocardial infarction (AMI), which is in accordance with weaken ischemia-induced neovascularization attributed to impaired mobilization of endothelial progenitor cells (EPCs) from bone marrow under diabetic condition.Amlodipine,as a calcium channel blocker which could partly inhibit serum ACE activity, has been demonstrated to increase NO release, ameliorate vascular endothelial function as well as alleviate ischemia-induced heart injury and ventricular remodeling.In the study, we investigated whether amlodipine could improve the angiogenic responses in a diabetic rat model with AMI, through activation of bone marrow-EPC mobilization, and observed cardiac function after treatment.
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