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The aim of the present study was to investigate the role of comorbidity on the outcome for the patient with peripheral T-cell lymphoma (PTCL) in a Chinese population.Fifty-six newly diagnosed PTCL patients aged over 60 years were enrolled between April 2008 and August2014 inour institution.The medical record including clinical parameter, pathological status and treatment of all patients were reviewed.Prognostic factors were assessed using univariate and multivariate analysis.Forty-one (73.2%) patients with Peripheral T-cell lymphoma,not otherwise specified (PTCL-NOS), 9 (16.1%) with angioimmunoblastic T-cell lymphoma (AITL), 6 (10.7%) with anaplastic large cell lymphoma (ALCL) were recruited in this study.Twenty-eight (50%) had at least one comorbidity.Univariate analysis showed that Eastern Cooperative Oncology Group (ECOG) (2-4), presence of B symptoms, IPI (3-5), Charlson comorbidity index (CCI) (≧ 2) were significantly associated with shorten overall survival (OS), whereas presence of B symptoms, IPI (3-5), CCI (≧ 2) with worsen progression-free survival (PFS).Multivariate analysis indicated that high CCI (≧ 2) and high IPI (3-5) were the poor independent prognostic factors for OS and PFS in the elder PTCL patients.In conclusion, comorbidity was identified as a new independent poor prognostic factor for elder patients with PTCL.