【摘 要】
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Purpose To explore the relationship between P53 gene and triple-negative breast cancer,and determine that whether P53 gene could be a new effective therapeutic target.Materials and methods We identifi
【机 构】
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Department of Oncology,General Hospital of Shenyang Military Region,Shenyang 110840,China
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Purpose To explore the relationship between P53 gene and triple-negative breast cancer,and determine that whether P53 gene could be a new effective therapeutic target.Materials and methods We identified studies with quantitative data on the relation of P53 gene and TNBC through searching 12 databases on line (Oct.1999-Oct.2009) and reviewing the references,which were written in English or Chinese.Summary estimates of odds ratio was calculated using the fixed-effects model or the random-effects model as appropriate.Results We identified 12 eligible studies with 1532 cases of TNBC patients and 6329 controls of non-TNBC patients.The test for homogeneity resulted in x2=200.16 (P<0.05),it showed significant heterogeneity so that a random effect model was applied.Our results showed that the expression of P53 gene could be much stronger in TNBC group than that in non-TNBC group (OR=2.10,95%CI=1.21-3.65).In ethnicity-subgroup analysis,we found that in Caucasian group,the expression of P53 gene were stronger in TNBC group (OR=2.60,95%CI=1.21-5.57),but there was no statistical significance in Asian group (OR=1.69,95%CI=0.83-3.45).Conclusions P53 gene could be an effective predictor and a good therapeutic target for TNBC patients in the future,especially in Caucasian.Further researches focusing on P53 gene would gain a breakthrough in the treatment of TNBC.
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