【摘 要】
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Enterococcus faecalis is a Gram-positive bacterium that natively colonizes the human gastrointestinal tract and opportunistically causes life-threatening infect
【出 处】
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2015 Genomics Frontiers Symposium(2015基因组学前沿研讨会)
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Enterococcus faecalis is a Gram-positive bacterium that natively colonizes the human gastrointestinal tract and opportunistically causes life-threatening infections.Multidrug-resistant (MDR) E.faecalis strains have emerged, reducing treatment options for these infections.MDR E.faecalis strains have large genomes containing mobile genetic elements (MGEs) that harbor genes for antibiotic resistance and virulence determinants.Bacteria commonly possess genome defense mechanisms to block MGE acquisition, and we hypothesize that these mechanisms have been compromised in MDR E.faecalis.In restriction-modification (R-M) defense, the bacterial genome is methylated at cytosine (C) or adenine (A) residues by a methyltransferase (MTase), such that non-self DNA can be distinguished from self DNA.A cognate restriction endonuclease digests improperly modified non-self DNA.Little is known about R-M in E.faecalis.
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