In-depth mapping of the mouse brain N-glycoproteome reveals widespread N-glycosylation of diverse br

• 作 者: Pan Fang Yu Xue Ming-qi Liu Wen-feng Zeng Yang Zhang Lei Zhang Xing Gao Guo-quan Yan Jun Yao Hua-li Shen Peng-yuan Yang
• 机 构: MinhangHospitalandInstitutesofBiomedicalSciences,FudanUniversity,Shanghai,ChinaDepartmentofChemistry
• 出 处: 2016年全国糖生物学学术会议
• 发表日期: 2016年8期
• 关键词: N-glycoproteomics Mouse brain Brain physiological activities Disease biomarker M

　　N-glycosylation is one of the most prominent and abundant posttranslational modifications of proteins.It is estimated that over 50%of mammalian proteins undergo glycosylation.However,the analysis of N-glycoproteins has been limited by the available analytical technology.