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Recent advances in biomedical research have offered a broad range of approaches and tools that enhance our capability to practice evidence-based medicine and evidence-based regulation and thereby to improve human health."Human-on-a-chip" and "human organ construct"micropHysiological systems are a new, emerging technology that has the potential to correlate in vivo with in vitro and simulate human organ systems.The human-on-a-chip technology basically uses in vitro human organ constructs in which the various cells communicate.