【摘 要】
：
Cancer is a complex disease involved with genomic,epigenomic,and gene expression aberrations.Integrating analysis of cancer genomic and transcriptomic data can help people to explore cancers comprehen
【机 构】
：
College of Electrical Engineering and Automation, Anhui University, Hefei, Anhui,China
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Cancer is a complex disease involved with genomic,epigenomic,and gene expression aberrations.Integrating analysis of cancer genomic and transcriptomic data can help people to explore cancers comprehensively.However,with a large volume of different omics and functional data being detected,there is still a major challenge to identify functional driver mutations or pathways,which are causally implicated in the process of oncogenesis and provide a selection growth advantage,from the so-called passenger mutations that accrue stochastically,but do not contribute to cancer development.
其他文献
The current epidemic of Zika virus (ZIKV) in the Americas is particularly alarming given its confirmed neuropathological associations,such as fetal microcephaly and Guillain-Barre syndrome.As most of
Motivation: Recent studies have illustrated association between copy number variations (CNVs) and particular tumor types.By the help of different high-throughput technologies,such as array-based compa
Background: Neuropeptides (NPs) play critical roles in synaptic signaling in various systems.NPs act as hormone,modulator,neurotransmitter and cytokine to regulate broad functions.NPs share the common
Due to the extensive complexity and high genetic heterogeneity of genetic alterations in cancer,comprehensively depicting the molecular mechanisms of cancer remains difficult.Characterizing functional
RNA-Seq has become one of the most widely used applications based on next-generation sequencing (NGS) technology.However,raw RNA-Seq data may have various quality issues,which can significantly distor
Autophagy is a highly conserved process for degrading cytoplasmic contents,determines cell survival or death,and regulates the cellular homeostasis.Besides core ATG proteins,a large number of regulato
Background: Recently,the prediction of gene function has become a hot issue and various methods have been used to predict system-levels function of genes.Within those feasible methods,gene co-expressi
Reconstruction of gene regulatory networks (GRNs) is of utmost interest to biologists and is vital for understanding the complex regulatory mechanisms within the cell.The outcome of the current algori
Gene regulations play vital roles in many fundamental biological processes in both transcription and post-transcription levels.Reverse engineering of genome-wide regulatory networks from high-throughp
Gene expression and regulation is the basis for a cells function.Various models have been built to investigate the behavior of it.Gene expression and regulation are based on complex bio-chemical inter