【摘 要】
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MicroRNA-203 (miR-203), possessing tumorsuppressive or promotive activities, has been found to bedownregulated or upregulated in different cancer types.The purpose of this study was to investigate whe
【机 构】
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Maternal and Child Health Hospital of Hainan Province,No.15,LongKunNan Road,Haikou 570206,Hainan,Chi
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MicroRNA-203 (miR-203), possessing tumorsuppressive or promotive activities, has been found to bedownregulated or upregulated in different cancer types.The purpose of this study was to investigate whether the increased expression of miR-203 can be used as a noninvasive diagnostic and prognostic biomarker in epithelial ovarian cancer (EOC).Real-time quantitative PCR was performed to detect the expression levels of miR-203 in EOC tissues.The expression levels of miR-203 were significantly higher in EOC tissues compared to adjacent noncancer oustissues (p<0.001).High expression of miR-203 was observed in 65.38% (102/156) of EOC.In addition,high miR-203 expression was found to be closely correlated with advanced FIGO stage (p<0.001), higher histological grade (p=0.02), lymph node involvement (p<0.001), and positive recurrence (p<0.001).Moreover, high miR-203 expression was correlated with shorter overall survival (p<0.001) and shorter progression-free survival (p<0.001) of EOC patients.Furthermore, multivariate analysis showed that the status of miR-203 expression was an independent predictor for both overall survival and progression-free survival in EOC.These findings provide the convincing evidence for the first time that the upregulation of miR-203 may serve as a novel molecular marker to predict the aggressive tumor progressionandun favorableprognosisofEOCpatients.
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