花生四烯酸细胞色素P450ω-羟化酶4A14在小鼠肝脏脂质代谢中的作用

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：lhcllk

【摘要】

：

目的：随着人们生活水平的提高，我国非酒精性脂肪肝的发病率越来越高。本文旨在探讨细胞色素P450 ω-羟化酶CYP4A14 在肝脏脂质代谢中的作用，以期为阐明非酒精性脂肪肝发生的机制提供线索。方法：(1)野生型(WT)及CYP4A14 基因敲除(4A14KO)小鼠分为如下四组：1)WT+普通饮食组；2)WT+高脂饮食组；3)4A14KO+普通饮食组；4)4A14KO+高脂饮食组。

【作者】

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管又飞李沙王春炅陈真真周云枫

【机构】

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北京大学医学部生理与病理生理学系,北京 100191 天津医科大学生理学系,天津 300070

【出处】

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中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

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2014年7期

【关键词】

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CYP4A14 非酒精性脂肪肝 FAT/CD36

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花生四烯酸细胞色素P450ω-羟化酶4A14在小鼠肝脏脂质代谢中的作用

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