Solid-phase Micro-extraction-Comprehensive Two- Dimensional Gas Chromatography to Analyze Breath VOC

• 作 者: Hongyong Ma
• 出 处: 第七届全国环境化学学术大会
• 发表日期: 2013年6期

　　Detailed compositional analyses of breath volatile organic compounds (VOCs) are often performed by one-dimensional techniques,such as GC/MS,PTR-MS,SIFT-MS etc.New developments in comprehensive two-dimensional gas chromatography (GC×GC) offer the prospect of providing more complete and quantitative compositional information of breath VOCs.In this study,an analytical procedure based on GC × GC combined with Solid-phase microextraction (SPME) for the simultaneous determination of propanol,acetone and methanol as biomarkers of lung cancer is presented.The results showed that lung cancer patients had much higher breath concentrations of propanol (7415.287 ng/L),acetone (1811.635 ng/L),methanol (225.0452 ng/L) than healthy controls(1975.259 ng/L,579.9679 ng/L,76.7626 ng/L,respectively).For 25 healthy controls,no significant relationship was fond between breath VOCs and gender,age,BMI.For 13 lung cancer patients,the concentrations of breath propanol,acetone,methanol in smokers and patients with diabetes were higher than these in non-smokers and nondiabetes,respectively.These findings may offer valuable and reliable information for the early diagnosis and prognosis of lung cancer.