【摘 要】
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Objective Alzheimers disease (AD) is characterized by overproduction of β amyloid peptides (Aβ) in the brain with progressive loss of neuronal cells.Some
【机 构】
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Department of Neurobiology, Shanxi Medical University, Taiyuan 030001, China
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Objective Alzheimers disease (AD) is characterized by overproduction of β amyloid peptides (Aβ) in the brain with progressive loss of neuronal cells.Some studies have showed that Aβ31-35,a shorter active fragment of Aβ,possesses the similar neurotoxicity as the full length of Aβ or Aβ25-35.Humanin (HN),a recently discovered rescue factor,is reported to protect neuronal cells from various AD-relevant.Previous studies in our lab have showed that Aβ31-35 can suppress the BK currents and prevent the repolarization of membrane and generation of the fast afler-hyperpolarization (fAHP).Meanwhile,it is generally accepted that the overloading of intracellular Ca2+ is an initial factor and one of the key mechanisms for multiple insults.Methods In the presence of HN,BK currents and voltage-dependent Ca2+ currents was surveyed by using whole cell patch clamp.And HN-induced [Ca2+]i was also detected by using calcium imaging.
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